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Nef--an adaptor adaptor?

J Oldridge·M Marsh
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Abstract

The Nef protein of human immunodeficiency virus (HIV) is a crucial factor in viral pathogenesis. One of the roles of this multifunctional protein is to decrease the cell-surface expression of CD4, a component of the virus receptor complex, and of MHC class I molecules. New results indicate that Nef can link CD4 to endocytic clathrin adaptor complexes and might also modulate other steps in the endocytic pathway.

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AnimalsCD4 AntigensEndocytosisGene Products, nefHistocompatibility Antigens Class IHumansJournal ArticleResearch Support, Non-U.S. Gov'tReview

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J Oldridge, M Marsh. 1998. Nef--an adaptor adaptor?. https://doi.org/10.1016/s0962-8924(98)01318-x

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