Gene and cell transfer for specific immunotherapy.

M K Brenner; H E Heslop; C M Rooney

doi:10.1111/j.1423-0410.1998.tb05401.x

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Gene and cell transfer for specific immunotherapy.

M K Brenner·H E Heslop·C M Rooney

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Abstract

The realisation that human tumor cells may express and process tumor specific and tumor associated antigens has increased interest in immunotherapeutic approaches to cancer treatment. This interest has been coupled with a burgeoning ability to genetically modify tumor cells and components of the immune system, in an effort to maximize the anti-neoplastic response. In a number of settings, gene modified tumor vaccines, cytotoxic T cells and dendritic cells are producing both immunomodulation and clinically evident benefits. Continued exploration of this approach seems well justified.

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Adenoviridae Apoptosis Bone Marrow Transplantation Cancer Vaccines Dendritic Cells Epstein-Barr Virus Infections Genetic Therapy Genetic Vectors Graft vs Tumor Effect Herpesvirus 4, Human Humans Immunotherapy, Adoptive Interleukin-2 Lymphoma, B-Cell Neoplasms Neoplastic Stem Cells T-Lymphocytes, Cytotoxic Journal Article Review

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M K Brenner, H E Heslop, C M Rooney. 1998. Gene and cell transfer for specific immunotherapy.. https://doi.org/10.1111/j.1423-0410.1998.tb05401.x

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