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CH domains revisited.

T Stradal·W Kranewitter·S J Winder·M Gimona
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Abstract

A sequence motif of about 100 amino acids, termed the 'calponin homology domain' has been suggested to confer actin binding to a variety of cytoskeletal and signalling molecules. Here we analyse and compare the sequences of all calponin homology domain-containing proteins identified to date. We propose that single calponin homology domains do not confer actin-binding per se and that the actin-binding motifs of cross-linking proteins, which comprise two disparate calponin homology domains, represent a unique protein module.

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ActinsAmino Acid SequenceAnimalsCalcium-Binding ProteinsDatabases, FactualHumansMicrofilament ProteinsMolecular Sequence DataPhylogenyProtein ConformationSequence Homology, Amino AcidCalponinsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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T Stradal, W Kranewitter, S J Winder, M Gimona. 1998-07-17. CH domains revisited.. https://doi.org/10.1016/s0014-5793(98)00751-0

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