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The depression system: preliminary studies.

D E Richardson·C W Dempsey·J H Song
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Abstract

The learned helplessness paradigm was used to test the notion that lesions of a theatrical depression system in the rat will produce antidepression similar to antidepressive medication. Lateral brain stem lesions were effective in producing antidepression and unilateral lesions were as effective as bilateral lesions. Ibotenic acid lesions were not effective, indicating that the effective target site was in a fiber tract and not a cell nucleus.

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AnimalsBehavior, AnimalBrain StemDepressive DisorderDisease Models, AnimalFunctional LateralityHelplessness, LearnedHumansImipramineNeural PathwaysRatsJournal Article

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D E Richardson, C W Dempsey, J H Song. 1997. The depression system: preliminary studies.. https://doi.org/10.1159/000099928

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