Allylamine type xanthone antimycotics.

I Salmoiraghi; M Rossi; P Valenti; P Da Re

doi:10.1002/(sici)1521-4184(199806)331:6<225::aid-ardp225>3.0.co;2-5

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PubMed · 9713256

Allylamine type xanthone antimycotics.

I Salmoiraghi·M Rossi·P Valenti·P Da Re

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Abstract

A number of xanthone derivatives bearing the basic chain of naftifine and butenafine antimycotics in 1, 2, 3, and 4 nuclear positions are described. The in vitro antifungal activity against representative strains of molds and yeasts is reported. Only butenafine xanthone analogues show significant activity against Cryptococcus neoformans, in particular the regioisomer 4d (1.5 micrograms/ml).

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Allylamine Antifungal Agents Aspergillus niger Benzylamines Candida albicans Cryptococcus neoformans Microbial Sensitivity Tests Naphthalenes Penicillium Structure-Activity Relationship Xanthenes Journal Article

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I Salmoiraghi, M Rossi, P Valenti, P Da Re. 1998. Allylamine type xanthone antimycotics.. https://doi.org/10.1002/(sici)1521-4184(199806)331%3A6%3C225%3A%3Aaid-ardp225%3E3.0.co%3B2-5

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