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Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence.

H Mochizuki·S W Scherer·T Xi·D C Nickle·M Majer·J J Huizenga·L C Tsui·M Prochazka
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Abstract

We report the cloning and characterization of human PON2, a paraoxonase-related gene-2 that is physically linked with PON1 and PON3 on 7q2l.3. PON2 is ubiquitously expressed and we identified several mRNA forms produced by alternative splicing, or by the use of a second transcription start site. We also describe two polymorphisms in the coding sequences that, in the protein deduced from the longest open reading frame, predict an alanine-to-glycine substitution at residue 147 and a serine-to-cysteine substitution at residue 310.

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Amino Acid SequenceAryldialkylphosphataseBase SequenceChromosome MappingChromosomes, Human, Pair 7Cloning, MolecularDiabetes Mellitus, Type 2Disease SusceptibilityEsterasesGenesHumansInsulin ResistanceIntronsMolecular Sequence DataOpen Reading FramesPolymorphism, GeneticRNA SplicingRNA, MessengerSequence AlignmentSequence Homology, Amino AcidTranscription, GeneticComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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H Mochizuki, S W Scherer, T Xi, D C Nickle, M Majer, J J Huizenga, L C Tsui, M Prochazka. 1998-06-15. Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence.. https://doi.org/10.1016/s0378-1119(98)00193-0

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