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PubMed · 9718019

Polymers that reduce intraperitoneal adhesion formation.

K Falk·L Holmdahl·M Halvarsson·K Larsson·B Lindman·S Bengmark
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Abstract

BACKGROUND: Viscous macromolecules and phospholipids have been shown to reduce postoperative adhesion formation. The ideal agent, or combination of agents, still remains to be identified. METHODS: The effect of hydrophobically modified ethyl (hydroxyethyl) cellulose (HM-EHEC) and polyquarternium-24 (LM-200), two cellulose-derived polymers, and of sphingomyelin, was examined in an animal model. Adhesions were induced in the parietal peritoneum in a standardized manner and quantity, and the morphology of adhesion formation was evaluated after 7 days. RESULTS: A significant reduction in adhesion formation was seen in animals receiving LM-200 (P=0.013) and HM-EHEC (P=0.012) as a short-term treatment compared with controls given saline, but not in animals receiving sphingomyelin (P=0.733). Additional effects were seen in the animals receiving LM-200 as a prolonged treatment (P< 0.001) compared with controls. There was no difference in the magnitude of the inflammatory response between the groups. CONCLUSION: These results suggest that hydrophobically modified polymers are efficient in reducing adhesions, without affecting the inflammatory response.

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AnimalsCelluloseFemaleMicePeritoneal DiseasesPolymersTissue AdhesionsJournal ArticleResearch Support, Non-U.S. Gov't

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K Falk, L Holmdahl, M Halvarsson, K Larsson, B Lindman, S Bengmark. 1998. Polymers that reduce intraperitoneal adhesion formation.. https://doi.org/10.1046/j.1365-2168.1998.00784.x

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