Structure-function aspects of prion proteins.

V Daggett

doi:10.1016/s0958-1669(98)80008-6

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Structure-function aspects of prion proteins.

V Daggett

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Abstract

Prions diseases are fatal neurodegenerative disorders resulting from conformational changes in the prion protein from the normal cellular form, PrPC, to the infectious scrapie isoform, PrPSc. High resolution structures for PrPC are now available, and biochemical investigations are shedding light on the nature and determinants of the conformational transition. Together, these studies are beginning to provide a framework to describe structure-function relationships of the prion protein.

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Animals Humans Magnetic Resonance Spectroscopy PrPC Proteins PrPSc Proteins Prions Protein Conformation Species Specificity Structure-Activity Relationship Journal Article Research Support, U.S. Gov't, P.H.S.Review

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V Daggett. 1998. Structure-function aspects of prion proteins.. https://doi.org/10.1016/s0958-1669(98)80008-6

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