Caspases: enemies within.

N A Thornberry; Y Lazebnik

doi:10.1126/science.281.5381.1312

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PubMed · 9721091

Caspases: enemies within.

N A Thornberry·Y Lazebnik

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Abstract

Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.

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Animals Apoptosis Catalysis Cysteine Endopeptidases Cysteine Proteinase Inhibitors Drug Therapy Enzyme Activation Enzyme Precursors Humans Neoplasms Substrate Specificity Journal Article Review

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N A Thornberry, Y Lazebnik. 1998-08-28. Caspases: enemies within.. https://doi.org/10.1126/science.281.5381.1312

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