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A sequential algorithm for the non-linear dual-sorption model of percutaneous drug absorption.

A B Gumel·K Kubota·E H Twizell
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Abstract

A sequential algorithm is developed for the non-linear dual-sorption model developed by Chandrasekaran et al. [1,2] which monitors pharmacokinetic profiles in percutaneous drug absorption. In the experimental study of percutaneous absorption, it is often observed that the lag-time decreases with the increase in the donor concentration when two or more donor concentrations of the same compound are used. The dual-sorption model has sometimes been employed to explain such experimental results. In this paper, it is shown that another feature observed after vehicle removal may also characterize the dual-sorption model. Soon after vehicle removal, the plots of the drug flux versus time become straight lines on a semilogarithmic scale as in the linear model, but the half-life is prolonged thereafter when the dual-sorption model prevails. The initial half-life after vehicle removal with a low donor concentration is longer than that with a higher donor concentration. These features, if observed in experiments, may be used as evidence to confirm that the dual-sorption model gives an explanation to the non-linear kinetic behaviour of a permeant.

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Administration, CutaneousAlgorithmsHalf-LifeLinear ModelsModels, BiologicalNumerical Analysis, Computer-AssistedPharmacokineticsSkin AbsorptionJournal Article

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BibTeXRIS

A B Gumel, K Kubota, E H Twizell. 1998-08-15. A sequential algorithm for the non-linear dual-sorption model of percutaneous drug absorption.. https://doi.org/10.1016/s0025-5564(98)10021-4

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