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Poor-risk germ cell tumors. Recent developments.

P M Dodd·R J Motzer·D F Bajorin
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Abstract

Standard therapy for patients with poor-risk germ cell tumors remains four cycles of bleomycin, etoposide, and cisplatin (BEP) chemotherapy, which cures approximately 50% of this patient population. Randomized trials of conventional-dose chemotherapy have failed to identify a regimen with superior efficacy to BEP. Preliminary data suggesting efficacy for high-dose chemotherapy with stem cell or autologous bone marrow transplantation as initial therapy for poor-risk disease have led to two randomized trials of this approach as initial therapy for poor-risk patients. The recently developed International Germ Cell Consensus Classification provides a standard method for determining poor-risk status and should be uniformly applied for both clinical decision making and risk assignment in clinical trials.

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Antineoplastic AgentsBiomarkers, TumorDrug Administration ScheduleGerminomaHumansMalePrognosisRiskRisk FactorsTesticular NeoplasmsJournal ArticleReview

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BibTeXRIS

P M Dodd, R J Motzer, D F Bajorin. 1998. Poor-risk germ cell tumors. Recent developments.. https://doi.org/10.1016/s0094-0143(05)70038-0

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