Four cholesterol-sensing proteins.

Y Lange; T L Steck

doi:10.1016/s0959-440x(98)80119-x

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PubMed · 9729733

Four cholesterol-sensing proteins.

Y Lange·T L Steck

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Abstract

What is the connection among the following three medical conditions: Niemann-Pick type C disease (a cause of mental retardation and early death), systemic lipidosis (in which an obscure side effect of numerous drugs transforms lysosomes into lamellar bodies), and holoprosencephaly (a catastrophe in embryonic development)? Recent evidence suggests that the pathogenesis in each use involves impaired sensing of cellular cholesterol.

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Carrier Proteins Cholesterol Holoprosencephaly Homeostasis Humans Hydroxymethylglutaryl CoA Reductases Intracellular Signaling Peptides and Proteins Lipidoses Membrane Glycoproteins Membrane Proteins Niemann-Pick C1 Protein Niemann-Pick Diseases Patched Receptors Proteins Receptors, Cell Surface Journal Article Review

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Y Lange, T L Steck. 1998. Four cholesterol-sensing proteins.. https://doi.org/10.1016/s0959-440x(98)80119-x

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