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PubMed · 973740

Low-tar and high-tar cigarettes.

P G Holt·J E Chalmer·L M Roberts·J M Papadimitriou·W R Thomas·D Keast
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Abstract

Mice were exposed for 7 to 8 minutes on weekdays to fresh smoke from high-tar (HT) or low-tar (LT) cigarettes for varying periods of up to 36 weeks. Mice exposed to HT cigarettes exhibited more marked alterations in humoral immune responsiveness, hematological profiles, and pulmonary pathologic findings than those exposed to LT cigarettes. However, cell-mediated immune responsiveness to both bacterial and tumor-specific antigens was depressed similarly in animals exposed to HT or LT cigarettes. Furthermore, the growth rates of subcutaneously established tumors were enhanced similarly in the two groups, with respect to those in control animals.

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AnimalsAntibodiesCarboxyhemoglobinCytotoxicity Tests, ImmunologicErythrocyte CountHematocritHemoglobinsImmunity, CellularLeukocyte CountLungLymphocytesMelanomaMiceMice, Inbred BALB CMice, Inbred C57BLNeoplasm MetastasisNeoplasms, ExperimentalSmokingTarsComparative StudyJournal Article

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P G Holt, J E Chalmer, L M Roberts, J M Papadimitriou, W R Thomas, D Keast. Low-tar and high-tar cigarettes.. https://doi.org/10.1080/00039896.1976.10667230

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