HIV: from molecular recognition to tissue pathogenesis.

L Margolis

doi:10.1016/s0014-5793(98)00858-8

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HIV: from molecular recognition to tissue pathogenesis.

L Margolis

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Abstract

Dramatic progress has been made recently in identifying both viral and cellular molecules responsible for binding and fusion of HIV-1 to target cells. In vivo, HIV-1 infection is transmitted by viruses that recognize chemokine receptor CCR5, while viruses isolated at later stages of HIV disease often recognize another chemokine receptor, CXCR4. It is still not understood how this molecular tropism of HIV-1 is translated into the virus' ability to compromise normal cell functions, which results in impairment of lymphoid tissue and causes AIDS. Here, we discuss how the new molecular findings might relate to HIV pathogenesis in cells and tissues.

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Acquired Immunodeficiency Syndrome HIV-1 Humans Lymphoid Tissue Receptors, CCR5 Receptors, CXCR4 Journal Article Review

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L Margolis. 1998-08-14. HIV: from molecular recognition to tissue pathogenesis.. https://doi.org/10.1016/s0014-5793(98)00858-8

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