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PubMed · 9743500

Fertilization defects in sperm from mice lacking fertilin beta.

C Cho·D O Bunch·J E Faure·E H Goulding·E M Eddy·P Primakoff·D G Myles
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Abstract

Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin beta were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.

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ADAM ProteinsAnimalsCalciumCell AdhesionCell MembraneFallopian TubesFemaleFertilinsMaleMembrane FusionMembrane GlycoproteinsMetalloendopeptidasesMiceMice, Inbred C57BLMice, KnockoutOvumSperm CapacitationSperm-Ovum InteractionsSpermatogenesisSpermatozoaZona PellucidaJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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C Cho, D O Bunch, J E Faure, E H Goulding, E M Eddy, P Primakoff, D G Myles. 1998-09-18. Fertilization defects in sperm from mice lacking fertilin beta.. https://doi.org/10.1126/science.281.5384.1857

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