PubMed · 9750059
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
1998-07-01. Panic-disorder treatment guidelines published.. https://doi.org/10.1093/ajhp%2F55.13.1352
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.
Explore the source record for details and available documents.
The reversible binding of ethacrynic acid was characterized by a difference circular dichroism method. A 2/1 stoichiometry was determined for the [drug]/[HSA] (human serum albumin) complex. The reversible binding of ethacrynic acid to HSA determines direct competition with ligands that selectivity bind to site II and to the fatty acid site. Furthermore, indirect competition was shown for ligands for site I (anti-cooperative) and to site III (cooperative).