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PubMed · 9750521

[Total androgen blockade--concept, theory, method and clinical application].

S Ozono·Y Hirao
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Abstract

There can be seen many investigations to examine the effects and benefits of total androgen blockade (TAB), combining an antiandrogen with surgical castration or a LH-RH analogue, for advanced prostate cancer. This review summarizes the concept, theory, method and clinical application of TAB. The concept of TAB was supported by reports that show a survival advantage using the combined blockade over LH-RH analogue alone. The theory of TAB proposes that suppression of all androgen production, adrenal and testicular androgen, should result in a better response than standard hormonal management such as castration and/or estrogens. In Japan, Chlormadinone acetate (100 mg twice daily) or Flutamide (375 mg three times daily) is orally administered and Leuprorelin acetate (3.75 mg every 4 weeks) or Goserelin acetate (3.6 mg every 4 weeks) is administered by hypodermic injection. There have been unresolved controversies surrounding this therapeutic modality, therefore future studies should help to define the role of TAB.

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Androgen AntagonistsAntineoplastic Agents, HormonalChlormadinone AcetateFlutamideGonadotropin-Releasing HormoneGoserelinHumansLeuprolideMaleNeoplasms, Hormone-DependentOrchiectomyProstatic NeoplasmsEnglish AbstractJournal ArticleReview

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S Ozono, Y Hirao. 1998. [Total androgen blockade--concept, theory, method and clinical application].. https://pubmed.ncbi.nlm.nih.gov/9750521/

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