Statistical modeling using preoperative prognostic variables in predicting extracapsular extension and progression after radical prostatectomy for prostate cancer.

J J Bauer; R R Connelly; I A Seterhenn; S Srivastava; D G McLeod; J W Moul

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PubMed · 9753987

Statistical modeling using preoperative prognostic variables in predicting extracapsular extension and progression after radical prostatectomy for prostate cancer.

J J Bauer·R R Connelly·I A Seterhenn·S Srivastava·D G McLeod·J W Moul

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Abstract

OBJECTIVE: To predict the risk of extracapsular extension and postoperative recurrence before radical prostatectomy (RP) for prostate cancer. METHODS: We performed multivariate Cox regression analysis on preoperative variables in 260 clinically localized prostate cancer patients who underwent RP. With these data, we constructed a relative risk of recurrence (Rr) equation and an equation to predict the probability of extracapsular extension (PECE) before RP. RESULTS: Rr is calculated as exp[(0.47 x race + 0.14 x PSAST) + (0.13 x worst biopsy Gleason sum) + (1.03 x stage T1c) + (1.55 x stage T2b,c)], where PSAST indicates a sigmoidal transformation of prostate-specific antigen. PECE is calculated as 1/[1 + exp(-Z)], where Z = -2.47 + 0.15 (PSAST) + 0.31 (worst biopsy Gleason sum) + 0.18 (race) + 0.16 (stage T1c) + 0.38 (stage T2b,c). CONCLUSION: These two equations can be used preoperatively to predict the probability of extracapsular disease and the risk of prostate-specific antigen recurrence in patients undergoing RP.

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Aged Disease Progression Follow-Up Studies Humans Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Predictive Value of Tests Prognosis Proportional Hazards Models Prostate-Specific Antigen Prostatectomy Prostatic Neoplasms Reproducibility of Results Risk Survival Analysis Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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J J Bauer, R R Connelly, I A Seterhenn, S Srivastava, D G McLeod, J W Moul. 1998. Statistical modeling using preoperative prognostic variables in predicting extracapsular extension and progression after radical prostatectomy for prostate cancer.. https://pubmed.ncbi.nlm.nih.gov/9753987/

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