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PubMed · 9759503

TGF-beta signal transduction.

J Massagué
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Abstract

The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-beta signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-beta and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders.

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Biological TransportDNA-Binding ProteinsGene Expression RegulationGenetic Diseases, InbornHumansNeoplasmsProtein Serine-Threonine KinasesReceptors, Transforming Growth Factor betaSignal TransductionSmad1 ProteinTrans-ActivatorsTransforming Growth Factor betaJournal ArticleReview

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J Massagué. 1998. TGF-beta signal transduction.. https://doi.org/10.1146/annurev.biochem.67.1.753

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