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Unusually high pacemaker threshold in severe myxedema. Decrease with thyroid hormone therapy.

D Basu·K Chatterjee
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Abstract

In a patient with myxedema and complete heart block, an usually high pacemaker threshold was observed initially during transvenous right ventricular endocardial pacing. The pacemaker threshold gradually decreased with thyroid replacement therapy, suggesting that the lack of thyroid hormone in some patients might increase the pacemaker threshold.

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Adams-Stokes SyndromeAgedHeart BlockHumansMaleMyxedemaPacemaker, ArtificialThyroxineCase ReportsJournal Article

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BibTeXRIS

D Basu, K Chatterjee. 1976. Unusually high pacemaker threshold in severe myxedema. Decrease with thyroid hormone therapy.. https://doi.org/10.1378/chest.70.5.677

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PubMed1992

[Integrated traditional and Western medicine treatment of severe viral myocarditis].

33 patients divided into 2 groups for treatment. Group A (18 cases) early use of adrenal cortico-steroid treatment in combination with traditional Chinese medicine; group B (15 cases): early use of adrenal cortico-steroid treatment is combination with interferon, then compared the therapeutic effects of these 2 groups. The results showed that, in these 2 groups, the sinus-atrial block, atrial ventricular block, ventricular tachycardia, acute pump failure as well as the EKG changes were relieved and improved to the same degree. In group A, after therapy, the parameters of OKT3 (%) was elevated from 51 +/- 15.22 to 55.23 +/- 8.53; OKT4(%) was elevated from 30.06 +/- 11.47 to 47.32 +/- 10.87; ratio of OKT4/OKT8 was elevated from 1.11 to 1.53; all of their P values were < 0.01. NK cell activity was elevated from 8.36 +/- 3.75 to 13.08 +/- 5.77, P value < 0.05. In group B, the parameters of OKT3 (%) was elevated from 50.91 +/- 8.12 to 56.75 +/- 8.29; OKT4 (%) was elevated from 32. 55 +/- 6.78 to 45.13 +/- 10.85; ratio of OKT4/OKT8 was elevated from 1.00 +/- 0.21 to 1.37 +/- 0.16; P value < 0.05, < 0.05 and < 0.01 respectively. NK cell activity (%) was elevated from 8.20 +/- 3.08 to 14. 0.3 +/- 4.89, P value also < 0.01. Hence, not only in group A but also in group B, after therapy, the parameters of OKT3,4,8, OKT4/OKT8 and NK cell activity (%) were all improved. But there was no significant statistical difference between group A and B.(ABSTRACT TRUNCATED AT 250 WORDS)

Adams-Stokes Syndrome↗
PubMed1992

Physiology of rate-responsive pacing.

The search for a pacemaker that accurately and easily mimics normal physiology is a continuing effort. There have been many achievements in the past, including sensing of the pacing chamber and programming of the pacing rate, sensitivity, and output. Present pacing developments include atrioventricular synchrony and rate adaptiveness. Results of studies on activation sequence and circadian variations will impact future pacing. The usefulness, cost effectiveness, and clinical value of some of the new pacing features remain unclear. Further clinical trials are necessary to clarify the value of new pacing techniques.

Adams-Stokes Syndrome↗