PubMed Health⌕ Search

PubMed · 9761036

Acute drug desensitization.

Abstract

Evidence is accumulating that supports a role for acute desensitization for IgE-mediated drug allergy in those patients for whom no alternative drug exists. While most of the studies have been performed in penicillin-allergic patients, this procedure has been used safely in patients with IgE sensitivity to other agents. In addition, it has been shown that modified desensitization protocols may be effective in the prevention of other immune-mediated drug reactions, as well. Thus, while much research remains to be done in this area, drug desensitization will continue to be a powerful tool in the management of drug allergy.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

R S Gruchalla. 1998. Acute drug desensitization.. https://pubmed.ncbi.nlm.nih.gov/9761036/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

[Current recommendations for the use of SCIT and SLIT].

Allergen specific immunotherapy (SIT) is the only potentially curative treatment of IgE mediated allergic diseases. To ensure its effective use, many requirements must be met before and during therapy. Before starting immunotherapy, informed consent should be obtained, along with the consideration of the indications and contraindications. SIT should be prescribed and administered only by physicians with experience in allergic disease who are qualified to manage severe anaphylactic reactions. The clinical symptoms and the age of the patients determine the route of application, choice of allergen extracts and the duration of treatment. Numerous products and protocols facilitate an individualised therapy.

Desensitization, Immunologic↗

Enhancing efficacy, safety, and convenience of immunotherapy: a workshop presentation.

OBJECTIVE: To discuss issues in delivering appropriate allergen immunotherapy. DATA SOURCES: Review of Immunotherapy Collegium II workshop presented at the 2005 Annual Meeting of the American College of Allergy, Asthma and Immunology. STUDY SELECTION: Topics discussed during Immunotherapy Collegium II. RESULTS: In the past, dosage schedules, levels, and rates of acceleration were linked to skin test results. The most recent published schedules for administration of immunotherapy do not reflect the initial reaction to the skin test, but leave it to the treating physician to factor in the results of testing with plans for administration in both increments and frequency. However, there are no official recommendations for physicians relevant to using a skin test to gauge patient sensitivity. Rather, allergists are advised to set up a maintenance concentrate and then make suitable dilutions when immunotherapy is initiated. CONCLUSION: Although recommendations are lacking regarding the use of a skin test to gauge patient sensitivity, official recommendations are clear in other areas of immunotherapy, such as the use of premedication. It is important that standard terms be adopted by all physicians who prescribe allergen immunotherapy and that modified allergens and/or oral immunotherapy be explored in the future to make immunotherapy more comfortable.

Desensitization, Immunologic↗