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PubMed · 9765645

[Mixed corticomedullary tumor].

I Delèvaux·J Cabane·O Picard·C Bénit·J Lebas·B Nordlinger·P de Saint-Maur·J C Imbert
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Abstract

BACKGROUND: Pheochromocytoma and primary hyperaldosteronism rarely occur simultaneously. Few cases have been reported in the literature. CASE REPORT: A patient explored for hypertension was found to have hypokalemia related to primary hyperaldosteronism. Pathology examination of the ablated adrenal showed a co-existing pheochromocytoma suspected at history taking although urine catecholamines were normal. DISCUSSION: Different pathogenic hypothesis have been proposed. Such dual tumors could be a simple coincidence, occur in a particular genetic setting, be related to direct contact between cortical and medullary tissue leading to reactional cortical hyperplasia, pheochromocytoma produced factors stimulating aldosterone synthesis, or factor X, a substance produced by cortical adenomas and favoring growth of the pheochromocytoma.

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Adrenal Gland NeoplasmsAdrenal GlandsHumansHyperaldosteronismHypertensionMaleMiddle AgedPheochromocytomaTomography, X-Ray ComputedCase ReportsJournal Article

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I Delèvaux, J Cabane, O Picard, C Bénit, J Lebas, B Nordlinger, P de Saint-Maur, J C Imbert. 1998-09-05. [Mixed corticomedullary tumor].. https://pubmed.ncbi.nlm.nih.gov/9765645/

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