Simultaneous analysis of multiple gene expression patterns as a function of development, injury or senescence.

J L Cook; V Marcheselli; J Alam; P L Deininger; N G Bazan

doi:10.1016/s1385-299x(98)00012-9

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Simultaneous analysis of multiple gene expression patterns as a function of development, injury or senescence.

J L Cook·V Marcheselli·J Alam·P L Deininger·N G Bazan

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Abstract

Concurrent changes in expression of eight genes were examined following cryogenic rat brain injury. Cortical RNA levels were catalogued at time 0, and at 1 h and 1 week following injury. The genes include thymidine kinase (TK), c-fos, renin, myelin basic protein (MBP), proteolipid protein (PLP), glial fibrillary acidic protein (GFAP), insulin-like growth factor-1 (IGF-1), and somatostatin. All demonstrate increased expression following injury. Renin and c-fos exhibit detectable changes as early as 1 h post-injury.

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Aging Animals Brain Injuries Gene Expression Regulation, Developmental Humans RNA, Messenger Rats Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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J L Cook, V Marcheselli, J Alam, P L Deininger, N G Bazan. 1998. Simultaneous analysis of multiple gene expression patterns as a function of development, injury or senescence.. https://doi.org/10.1016/s1385-299x(98)00012-9

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