Fc-binding molecules specific for human IgG1 and IgG3 are present in Echinococcus granulosus protoscoleces.

A Baz; H Carol; M Marco; L Casabó; F Jones; D Dunne; A Nieto

doi:10.1046/j.1365-3024.1998.00147.x

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Fc-binding molecules specific for human IgG1 and IgG3 are present in Echinococcus granulosus protoscoleces.

A Baz·H Carol·M Marco·L Casabó·F Jones·D Dunne·A Nieto

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Abstract

In this work we describe the presence of Fc-binding activity on the suckers and tegument of E. granulosus protoscoleces. A fraction (PSA-Fc+) from protoscolex somatic antigens was isolated by affinity chromatography on human Fc-gamma1-Sepharose. Analysis by SDS-PAGE of PSA-Fc+ showed that it contained two major components. Using mouse F(ab')2-human Fc chimaeric monoclonal antibodies we verified that PSA-Fc+ bound mainly to human Fc-gamma1 and Fc-gamma3 isotypes. In addition, one of the components of PSA-Fc+ showed proteolytic activity. Both, Fc-binding and proteolytic activities localized on the protoscolex surface, may play a relevant role in the host-parasite interaction.

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Animals Antibodies, Helminth Antibodies, Monoclonal Antigens, Helminth Echinococcus Host-Parasite Interactions Humans Immunoglobulin Fc Fragments Immunoglobulin G Mice Receptors, Fc Journal Article Research Support, Non-U.S. Gov't

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A Baz, H Carol, M Marco, L Casabó, F Jones, D Dunne, A Nieto. 1998. Fc-binding molecules specific for human IgG1 and IgG3 are present in Echinococcus granulosus protoscoleces.. https://doi.org/10.1046/j.1365-3024.1998.00147.x

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