[The pathologic system].

Abstract

The pathological system (PS) is a new pathological integration originating from the primary and secondary altered CNS structure, whose activity has a dysadaptive or direct pathogenic significance for the body. An important role in the formation of PS is played by hyperactive CNS structure which acquires the role of a pathological determinant. Disturbances in the inhibitory mechanisms of CNS structures involved in the PS and enhanced excitability of their neurons promote the formation of PS. Negative feedbacks in PS are ineffective due to the competence of inhibitory mechanisms in the determinant and other parts of the system. Owing to their permanent activation, positive intrasystemic feedbacks are stabilized by plasticity processes. All these changes promote the stabilization of PS and the increase of its resistance to endogenous corrective influences. The major pathogenetic significance of PS is that it is a pathophysiological basis of the respective syndrome. Every neuropathological syndrome has PS of its own. By creating a generator in the definite, pathogenetically significant structure of CNS, one can convert this structure into the pathological determinant, which induces the appropriate PS and thus causes the respective neuropathological syndrome. Hyperactive PSs suppress the physiological systems by causing disturbances in CNS activity.