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PubMed · 9772541

[The decrease of gastric mucosal blood flow in obstructive jaundice under stress].

N Yang·W Xu·J Duan
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Abstract

OBJECTIVE: To investigate the cause of decrease of gastric mucosal blood flow (GMBF) in obstructive jaundice under stress. METHODS: With common bile duct ligation (CBDL) in Wistar rats under cold restraint stress, GMBF and the content of Endothelin-1, Angiotensin-II, H2, alpha 1 receptor in gastric mucosa were measured. Before stress anti-ET-1 serum, Enalapril, Cimentidine and Phetolamins were administrated, and the change of GMBF was studied. RESULTS: GMBF was significantly decreased in CBDL in stress than those in control subjects. The content of ET1 and Ang-II was significantly increaced, the density of H2 and alpha 1 receptor was significantly decreased. Before stress antagonist was administrated, and GMBF was significantly increased. CONCLUSION: GMBF was decreased by increased ET, Ang-II and decreased H2, alpha 1 receptor in CBDL, under stress. Antagonist improved gastric mucosal blood flow. They had protection from gastric mucosa.

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Angiotensin IIAnimalsCholestasisCold TemperatureEndothelin-1Gastric MucosaMaleRatsRats, WistarReceptors, Histamine H2Regional Blood FlowStomach UlcerStress, PhysiologicalEnglish AbstractJournal Article

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N Yang, W Xu, J Duan. 1997. [The decrease of gastric mucosal blood flow in obstructive jaundice under stress].. https://pubmed.ncbi.nlm.nih.gov/9772541/

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