Protein interactions implicated in neurotransmitter release.

O el Far; V O'Connor; T Dresbach; L Pellegrini; W DeBello; F Schweizer; G Augustine; C Heuss; T Schäfer; M P Charlton; H Betz

doi:10.1016/s0928-4257(98)80150-2

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Protein interactions implicated in neurotransmitter release.

O el Far·V O'Connor·T Dresbach·L Pellegrini·W DeBello·F Schweizer·G Augustine·C Heuss·T Schäfer·M P Charlton·H Betz

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Abstract

Biochemical evidence indicates that the exocytotic release of neurotransmitters involves both evolutionary conserved membrane proteins, the SNAREs, as well as ubiquitous cytosolic fusion proteins, NSF and SNAPs. We have analyzed the biochemical properties and the physiological effects of these proteins. Our data suggest models how NSF, SNAPs and SNAREs may function in neurotransmitter exocytosis.

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Adenosine Triphosphatases Amino Acid Sequence Animals Carrier Proteins Conserved Sequence Evolution, Molecular Exocytosis Membrane Proteins Models, Molecular Models, Neurological N-Ethylmaleimide-Sensitive Proteins Nerve Tissue Proteins Neurotransmitter Agents SNARE Proteins Synaptosomal-Associated Protein 25 Vesicular Transport Proteins Journal Article Research Support, Non-U.S. Gov't Review

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O el Far, V O'Connor, T Dresbach, L Pellegrini, W DeBello, F Schweizer, G Augustine, C Heuss, T Schäfer, M P Charlton, H Betz. 1998. Protein interactions implicated in neurotransmitter release.. https://doi.org/10.1016/s0928-4257(98)80150-2

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