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PubMed · 9782898

Hormone replacement therapy.

Abstract

For the large number of women who become menopausal each year, the decision of whether to use hormone replacement therapy is central. The author outlines treatment options, risks, and benefits of hormone therapy and examines likelihoods of outcomes. Based on the latest research, types of hormones available, prescription regimens, side effects, and alternatives to hormone therapy are discussed.

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BibTeXRIS

M E Rousseau. 1998. Hormone replacement therapy.. https://pubmed.ncbi.nlm.nih.gov/9782898/

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Effects of hormone replacement therapy on lipid peroxides and oxidation system in postmenopausal women.

A short-term evaluation of 6 months of estrogen therapy on oxidant status in 38 postmenopausal women was conducted. The levels of serum lipid peroxidation products, glutathione (GSH) status, and glutathione-related enzymes were evaluated before and after 6 months of hormone replacement therapy. After 6 months of estrogen treatment there was a significantly increased concentration of thiobarbituric acid-reactive substances (TBARS), which are an end product of lipid peroxidation. This was accompanied by a significant increase in the activity of glutathione peroxidase (GSH-Px). However, the activities of glutathione reductase (GSSG-R) and superoxide dismutase (SOD) were significantly decreased and total protein thiols were reduced. Data suggest that hormone replacement therapy in postmenopausal women is associated with oxidant mechanisms.

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