Structure-specific DNA cleavage by 5' nucleases.

T A Ceska; J R Sayers

doi:10.1016/s0968-0004(98)01259-6

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PubMed · 9787638

Structure-specific DNA cleavage by 5' nucleases.

T A Ceska·J R Sayers

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Abstract

Many processes, such as DNA replication, recombination and repair, produce branched DNA structures. These bifurcated molecules are trimmed by a group of homologous 5'-3' exonucleases (also known as 5' nucleases) in structure-specific cleavage reactions. X-ray crystallographical and biochemical studies suggest that ssDNA substrates become threaded through the 5'-3' exonucleases, where hydrolysis is effected with the aid of divalent metal cations.

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Amino Acid Sequence Catalytic Domain DNA DNA Replication Exodeoxyribonucleases Models, Molecular Molecular Sequence Data Protein Conformation Sequence Homology, Amino Acid Journal Article Research Support, Non-U.S. Gov't Review

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T A Ceska, J R Sayers. 1998. Structure-specific DNA cleavage by 5' nucleases.. https://doi.org/10.1016/s0968-0004(98)01259-6

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