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PubMed · 9789809

TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo.

T Debeir·H U Saragovi·A C Cuello
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Abstract

Cholinergic neurons are known to respond in vivo to the administration of nerve growth factor (NGF) by a prominent and selective increase of choline acetyl transferase activity and by cholinergic synaptogenesis in the rat brain. By using a synthetic TrkA antagonist we demonstrated that endogenously produced NGF is involved in the continual re-modeling of cholinergic neuronal connections during adulthood, acting through TrkA receptors.

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AcetylcholineAnimalsCells, CulturedCerebral CortexCholine O-AcetyltransferaseEnzyme InductionNerve Growth FactorsPeptides, CyclicPresynaptic TerminalsProto-Oncogene ProteinsRatsRats, Sprague-DawleyReceptor Protein-Tyrosine KinasesReceptor, trkAReceptors, Nerve Growth FactorSynapsesJournal ArticleResearch Support, Non-U.S. Gov't

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T Debeir, H U Saragovi, A C Cuello. TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo.. https://doi.org/10.1016/s0928-4257(98)80011-9

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