STAT structure and function in signaling.

T Hoey; U Schindler

doi:10.1016/s0959-437x(98)80015-4

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STAT structure and function in signaling.

T Hoey·U Schindler

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Abstract

The phenotypes of various STAT knockout mice reveal an unexpected specificity in the biological roles of these molecules. The mechanisms involved in generating selectivity and modulating STAT activity have been the focus of intense studies. This work has led to the discovery of novel families of proteins that regulate Jak-STAT signaling. Recently, the structures of a STAT dimer/DNA complex and of the amino-terminal domain have been solved, providing new insights into the function of these versatile proteins.

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Animals DNA-Binding Proteins Dimerization Gene Expression Regulation Mice Mice, Knockout Models, Biological Multigene Family Protein-Tyrosine Kinases Signal Transduction Trans-Activators Transcription Factors Journal Article Review

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T Hoey, U Schindler. 1998. STAT structure and function in signaling.. https://doi.org/10.1016/s0959-437x(98)80015-4

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