Combinatorial transcription factors.

C Wolberger

doi:10.1016/s0959-437x(98)80010-5

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Combinatorial transcription factors.

C Wolberger

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Abstract

Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes. Three-dimensional structures have been determined of the MATalpha2/MCM1-DNA complex, the p50/p65 Rel homology domain heterodimer bound to DNA, the NFAT/Fos-Jun/DNA quaternary complex, and of the GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA.

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Animals DNA Dimerization Humans Macromolecular Substances Models, Molecular Multiprotein Complexes Nucleic Acid Conformation Protein Conformation Protein Structure, Secondary Transcription Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Review

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C Wolberger. 1998. Combinatorial transcription factors.. https://doi.org/10.1016/s0959-437x(98)80010-5

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