How do cytotoxic lymphocytes kill their targets?

S Shresta; C T Pham; D A Thomas; T A Graubert; T J Ley

doi:10.1016/s0952-7915(98)80227-6

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PubMed · 9794837

How do cytotoxic lymphocytes kill their targets?

S Shresta·C T Pham·D A Thomas·T A Graubert·T J Ley

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Abstract

CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.

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Animals Apoptosis CD4-Positive T-Lymphocytes Cytotoxicity, Immunologic Granzymes Humans Membrane Glycoproteins Perforin Pore Forming Cytotoxic Proteins Serine Endopeptidases T-Lymphocytes, Cytotoxic fas Receptor Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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S Shresta, C T Pham, D A Thomas, T A Graubert, T J Ley. 1998. How do cytotoxic lymphocytes kill their targets?. https://doi.org/10.1016/s0952-7915(98)80227-6

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