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PubMed · 9796326

[Calcium channel blocker].

H Matsuoka
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Abstract

In the treatment of coronary heart disease, augmentation of oxygen supply and reduction of oxygen demand are necessary. Calcium antagonists (CA) have potent coronary vasodilating (augmentation of oxygen supply) and hypotensive (reduction of oxygen demand) effects without serious side effects, and are most popular agents in the treatment of coronary heart disease (CHD) and hypertension. Short acting CA are reported to be risks for coronary heart disease presumably due to a steal phenomenon, a marked hypotensive effect, and an increased sympathetic nerve activity. Therefore, nowadays long acting CA are usually used in the treatment of CHD and hypertension. However, long term treatment effects of long acting CA in patients with CHD are not clear. Further clinical trials (including primary prevention) concerning long acting CA are needed.

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Acute DiseaseCalcium Channel BlockersClinical Trials as TopicCoronary DiseaseHumansHypertensionSympathetic Nervous SystemSyndromeEnglish AbstractJournal ArticleReview

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H Matsuoka. 1998. [Calcium channel blocker].. https://pubmed.ncbi.nlm.nih.gov/9796326/

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