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PubMed · 9819301

Occupational asthma by Anisakis simplex.

A Armentia·M Lombardero·A Callejo·J M Martín Santos·F J Gil·J Vega·M L Arranz·C Martínez
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Abstract

BACKGROUND: No cases of occupational asthma caused by the inhalation of antigens from Anisakis simplex have been published. OBJECTIVE: The purpose of this study was to evaluate the possibility that A simplex can play a role in the asthma experienced by 2 workers when handling fish and fish flour. METHODS: Skin prick and bronchial challenge tests with A simplex were performed. We also carried out measurements of specific IgE to A simplex and immunoblotting. RESULTS: Both patients had strong positive skin test responses, challenge test responses, and specific IgE to A simplex. Immunoblotting showed that both patients also had IgE against several bands in the fish flour extract, suggesting contamination by Anisakis allergens. CONCLUSION: These 2 patients provide evidence for occupational asthma caused by A simplex, based on in vivo and in vitro tests for Anisakis-specific IgE.

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AllergensAnimalsAnisakisAntigens, HelminthAsthmaBronchial Provocation TestsChickensFish FlourHumansImmunoglobulin EMaleMiddle AgedOccupational DiseasesPoultry DiseasesSkin TestsCase ReportsJournal Article

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A Armentia, M Lombardero, A Callejo, J M Martín Santos, F J Gil, J Vega, M L Arranz, C Martínez. 1998. Occupational asthma by Anisakis simplex.. https://doi.org/10.1016/s0091-6749(98)70024-7

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