Granulocyte colony-stimulating factor administered as a single intraperitoneal injection modifies the lethal dose95/30 in irradiated B6D2F1 mice.

A Sureda; E Kádár; A Valls; J García-López

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PubMed · 9825589

Granulocyte colony-stimulating factor administered as a single intraperitoneal injection modifies the lethal dose95/30 in irradiated B6D2F1 mice.

A Sureda·E Kádár·A Valls·J García-López

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Abstract

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that stimulates the proliferation of progenitor myeloid cells. We have previously demonstrated that recombinant human G-CSF (rhG-CSF) significantly improves survival of lethally irradiated B6D2F1 mice when administered as a single intraperitoneal dose of 1 mg/kg 2 hours after a lethal dose (LD)95/30 irradiation. In our model, rhG-CSF is also able to modify the LD95/30 in irradiated animals and 1.1 has been found to be the dose modification factor (the ratio of LD95/30 for mice treated with rhG-CSF to that for control animals).

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Animals Bone Marrow Diseases Cell Survival Dose-Response Relationship, Radiation Female Granulocyte Colony-Stimulating Factor Humans Injections, Intraperitoneal Mice Radiation Injuries, Experimental Recombinant Fusion Proteins Letter Research Support, Non-U.S. Gov't

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A Sureda, E Kádár, A Valls, J García-López. 1998. Granulocyte colony-stimulating factor administered as a single intraperitoneal injection modifies the lethal dose95/30 in irradiated B6D2F1 mice.. https://pubmed.ncbi.nlm.nih.gov/9825589/

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