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dMi-2, a hunchback-interacting protein that functions in polycomb repression.

J Kehle·D Beuchle·S Treuheit·B Christen·J A Kennison·M Bienz·J Müller
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Abstract

Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically required for the repression of HOX genes. Genetic analyses show that dMi-2 participates in both Hunchback and Polycomb repression in vivo. Hence, recruitment of dMi-2 may serve as a link between repression of HOX genes by Hunchback and Polycomb proteins.

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Adenosine TriphosphatasesAnimalsAutoantigensCarrier ProteinsDNA-Binding ProteinsDrosophilaDrosophila ProteinsEmbryo, NonmammalianGene DosageGene Expression Regulation, DevelopmentalGenes, HomeoboxGenes, InsectGenetic Complementation TestGerm CellsHeterozygoteHomeodomain ProteinsIn Situ HybridizationInsect ProteinsMutationPolycomb Repressive Complex 1Recombinant Fusion ProteinsTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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J Kehle, D Beuchle, S Treuheit, B Christen, J A Kennison, M Bienz, J Müller. 1998-12-04. dMi-2, a hunchback-interacting protein that functions in polycomb repression.. https://doi.org/10.1126/science.282.5395.1897

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