Human developmental toxicity and mutagenesis.

H S Rosenkranz; Y P Zhang; O T Macina; D R Mattison; G Klopman

doi:10.1016/s0027-5107(98)00170-5

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PubMed · 9838188

Human developmental toxicity and mutagenesis.

H S Rosenkranz·Y P Zhang·O T Macina·D R Mattison·G Klopman

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Abstract

A previously described SAR model of human developmental toxicity was analyzed further. The model shows a number of mechanistic similarities with SAR models of other toxicological phenomena (systemic toxicity, chromosomal and genomic effects). This implies that there are many targets associated with developmental effects. Surprisingly the analyses revealed no significant mechanistic overlap between developmental toxicity in humans and mutagenicity in Salmonella, a surrogate for the occurrence of point mutations. Our study indicates that this lack of similarity is likely the result of the pre-screening strategies which largely eliminate Salmonella mutagens from among the therapeutics introduced into human medicine.

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Animals Child Development Child, Preschool Databases, Factual Drug Evaluation, Preclinical Embryonic and Fetal Development Humans Models, Theoretical Mutagenicity Tests Salmonella Structure-Activity Relationship Journal Article

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H S Rosenkranz, Y P Zhang, O T Macina, D R Mattison, G Klopman. 1998-12-03. Human developmental toxicity and mutagenesis.. https://doi.org/10.1016/s0027-5107(98)00170-5

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