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PubMed · 9845998

Which cough mixture?

F Mitchelson
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Abstract

BACKGROUND: Coughing is a defence mechanism to clear the airways but if it becomes ineffective, excessive or persistent it may cause fatigue and impair body function as well as create social problems for the patient. OBJECTIVE: Numerous preparations are available for the alleviation of cough, many containing multiple ingredients including antitussives, expectorants, mucolytics and decongestants. Their modes of action are examined and evidence for their usefulness in treating various types of cough evaluated. DISCUSSION: The use of various preparations in non-productive cough, drug induced cough and productive cough are discussed.

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Antitussive AgentsBronchodilator AgentsCoughExpectorantsHumansTreatment OutcomeJournal ArticleReview

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F Mitchelson. 1998. Which cough mixture?. https://pubmed.ncbi.nlm.nih.gov/9845998/

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PubMed1998

Simultaneous determination of dextromethorphan HBr and bromhexine HCl in tablets by first-derivative spectrophotometry.

A rapid, simple and direct assay procedure based on first-derivative spectrophotometry, using a zero-crossing and peak-to-base measurement at 234 and 324 nm, respectively, has been developed for the specific determination of dextromethorphan HBr and bromhexine HCl in tablets. Calibration graphs were linear with the correlation coefficients of 0.9999 for both analytes. The limit of detections were 0.033 and 0.103 microgram ml-1 for dextromethorphan HBr and bromhexine HCl, respectively. A HPLC method has been developed as the reference method. The results obtained by the first-derivative spectrophotometry were in good agreement with those found by the HPLC method.

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