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PubMed · 9846497

Immediate postoperative 5-FU does not decrease colonic anastomotic strength.

G P Yazdi·B W Miedema·L Humphrey
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Abstract

BACKGROUND AND OBJECTIVES: The use of continuous infusion 5-Fluorouracil (5-FU) immediately after surgery may improve the adjuvant treatment of resected colon cancer and is the subject of a national phase III trial (Intergroup no. 0136). The aim was to determine the effect of continuous infusion 5-FU on the bursting pressure of a colon anastomosis. METHODS: Twenty Lewis rats weighing approximately 300 g were subject to sigmoid colectomy and single-layer anastomosis. Ten rats received 5-FU continuously at 600 mg/m2 per day for 7 days; 10 rats served as controls. Ten days postoperatively, the rats were sacrificed and bursting pressure of the colon containing the anastomosis was determined. RESULTS: No anastomotic leaks or intra-abdominal abscesses were identified. Burst pressure of the colon in controls (124+/-13 mm Hg; mean+/-SEM) was not significantly different from those animals receiving 5-FU (115+/-9, P > 0.05). The control rats gained weight (13+/-7 g), which is significantly different from the rats receiving 5-FU (-19+/-13, P=0.04). CONCLUSIONS: Continuous infusion 5-FU postoperatively results in weight loss, but does not affect anastomotic bursting strength in rats. This evidence supports the safety of continuous infusion 5-FU postoperatively in humans.

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Anastomosis, SurgicalAnimalsAntimetabolites, AntineoplasticBiomechanical PhenomenaColonFluorouracilPostoperative PeriodRatsRats, Inbred LewJournal Article

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G P Yazdi, B W Miedema, L Humphrey. 1998. Immediate postoperative 5-FU does not decrease colonic anastomotic strength.. https://doi.org/10.1002/(sici)1096-9098(199811)69%3A3%3C125%3A%3Aaid-jso2%3E3.0.co%3B2-y

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