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PubMed · 9850862

CD4/CD8 lineage commitment: matching fate with competence.

S Chan·M Correia-Neves·C Benoist·D Mathis
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Abstract

The outcome of positive selection of T lymphocytes is that there is a close match between the lineage adopted by a particular cell (CD4+ or CD8+) and the specificity of the T-cell receptor for the class of Major Histocompatibility Complex molecule recognized. How this match is obtained has been a matter of debate. We review the evidence, from recent and older experiments, that indicates that the process follows a selective logic, rather than an instructive one.

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AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell LineageHumansJournal ArticleResearch Support, Non-U.S. Gov'tReview

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S Chan, M Correia-Neves, C Benoist, D Mathis. 1998. CD4/CD8 lineage commitment: matching fate with competence.. https://doi.org/10.1111/j.1600-065x.1998.tb01240.x

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