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PubMed · 9855032

The conditional binomial test revisited for clinical trials.

X Lei·D Davis·L Kuan·J Lee·S Oh
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Abstract

McNemar's test is used to test the hypothesis that one treatment is better than another in a matched-pair design for binary outcomes. The conditional binomial test in such a matched-pair design is the exact McNemar test. However, in many clinical trials, one wants to establish equivalency between two treatments. We discuss how to use a conditional binomial test to establish equivalency between two treatments in a matched-pair design. Sample size and power determination for each conditional binomial test are calculated. Some statistical properties of the tests are analyzed through Monte Carlo simulation.

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Binomial DistributionClinical Trials as TopicHumansMonte Carlo MethodTherapeutic EquivalencyJournal Article

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X Lei, D Davis, L Kuan, J Lee, S Oh. 1998. The conditional binomial test revisited for clinical trials.. https://doi.org/10.1080/10543409808835258

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