Progress and pitfalls: bipolar molecular linkage studies.

W Berrettini

doi:10.1016/s0165-0327(98)00020-2

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Progress and pitfalls: bipolar molecular linkage studies.

W Berrettini

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Abstract

This paper reviews the history of molecular genetic linkage studies of bipolar disorder. The topic is introduced with a brief discussion of various genetic concepts, including linkage, lod scores and non-parametric statistics. It is emphasized that criteria for declaring linkage must include independent confirmation by a second group of investigators. Given that the inherited susceptibility for bipolar disorder is most likely explained by multiple genes of small effect, simulations indicate that universal confirmation of valid linkages cannot be expected. With this background, several valid linkages of BP disorder to genomic regions are reviewed. These valid linkages include 18p11, 18q22, 21q21, Xq26 and 4pter. The issue of anticipation and expanding triplet repeats is discussed. Finally, there is a brief section on recommendations for future genetic linkage studies of bipolar disorder.

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Bipolar Disorder Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 16 Chromosomes, Human, Pair 18 Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 22 Chromosomes, Human, Pair 4 Genetic Linkage Genetic Predisposition to Disease Humans Pedigree Reproducibility of Results Research Design Trinucleotide Repeats X Chromosome Journal Article Research Support, U.S. Gov't, P.H.S.Review

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W Berrettini. 1998. Progress and pitfalls: bipolar molecular linkage studies.. https://doi.org/10.1016/s0165-0327(98)00020-2

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