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NSF--fusion and beyond.

A Haas
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Abstract

NSF (N-ethylmaleimide-sensitive fusion protein) was the first protein to be isolated as a crucial factor in intracellular membrane-fusion events, such as the fusion of synaptic vesicles with the presynaptic membrane during neurotransmission. Although the activation of membrane SNARE proteins for subsequent fusion is clearly a primary role of NSF, recent studies have provided surprising evidence that NSF also interacts with glutamate receptors at the postsynaptic membrane in a way that does not seem to involve SNAREs. These results suggest that NSF might act as a molecular chaperone not only on SNAREs but also of other proteins.

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AnimalsCarrier ProteinsEthylmaleimideMembrane ProteinsN-Ethylmaleimide-Sensitive ProteinsReceptors, AMPASNARE ProteinsVesicular Transport ProteinsJournal ArticleReview

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BibTeXRIS

A Haas. 1998. NSF--fusion and beyond.. https://doi.org/10.1016/s0962-8924(98)01388-9

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