Cyclin E overexpression in human gallbladder carcinomas.

N Eguchi; K Fujii; A Tsuchida; S Yamamoto; T Sasaki; G Kajiyama

doi:10.3892/or.6.1.93

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Cyclin E overexpression in human gallbladder carcinomas.

N Eguchi·K Fujii·A Tsuchida·S Yamamoto·T Sasaki·G Kajiyama

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Abstract

The expression of cyclin E, one of the important positive cell cycle regulators, was examined immunohistochemically in gallbladder carcinomas. Cyclin E gene product was detected in 58 (49%) out of 118 cases. The degree of cyclin E expression was not associated with any clinicopathological factor including histology, the depth of tumor invasion, tumor stage and patient prognosis. Cyclin E expression was not correlated with that of p53 protein statistically, whereas it was correlated with the proliferative activity of the tumor cells by PCNA (p<0.05). These results suggested that cyclin E expression may confer progression of gallbladder carcinomas.

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Biomarkers Blotting, Western Carcinoma Cell Cycle Cell Division Cyclin E Disease Progression Gallbladder Neoplasms Humans Neoplasm Proteins Proliferating Cell Nuclear Antigen Journal Article Research Support, Non-U.S. Gov't

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N Eguchi, K Fujii, A Tsuchida, S Yamamoto, T Sasaki, G Kajiyama. Cyclin E overexpression in human gallbladder carcinomas.. https://doi.org/10.3892/or.6.1.93

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