Serotonergic ergoline derivatives.

S Mantegani; E Brambilla; C Caccia; G Damiani; M G Fornaretto; R A McArthur; M Varasi

doi:10.1016/s0960-894x(98)00166-8

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PubMed · 9871719

Serotonergic ergoline derivatives.

S Mantegani·E Brambilla·C Caccia·G Damiani·M G Fornaretto·R A McArthur·M Varasi

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Abstract

Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT1A or 5-HT2 affinity and selectivity respectively.

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Animals Binding, Competitive Drug Design Ergolines Hippocampus Indicators and Reagents Prefrontal Cortex Radioligand Assay Rats Receptors, Adrenergic, alpha Receptors, Dopamine Receptors, Serotonin Receptors, Serotonin, 5-HT1 Serotonin Receptor Agonists Structure-Activity Relationship Journal Article

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S Mantegani, E Brambilla, C Caccia, G Damiani, M G Fornaretto, R A McArthur, M Varasi. 1998-05-05. Serotonergic ergoline derivatives.. https://doi.org/10.1016/s0960-894x(98)00166-8

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