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PubMed · 9873542

Investigating highly crosslinked macroporous resins for solid-phase synthesis.

M Hori·D J Gravert·P Wentworth·K D Janda
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Abstract

The washing efficiencies of a chromophore and the reaction rates of a classical esterification reaction are improved with macroporous resins (MRs) relative to a classical Merrifield resin. Furthermore, Wacker-oxidation of a MR bound alkene yielded the expected methylketone product whereas an alkene bound to a low-crosslinked Merrifield resin gave no product, a function of the relative permeability of each of these resins to the aqueous solvent conditions employed.

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Cross-Linking ReagentsDrug DesignEstersKetonesKineticsMolecular ConformationMolecular StructureResins, SyntheticStructure-Activity RelationshipSurface PropertiesComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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M Hori, D J Gravert, P Wentworth, K D Janda. 1998-09-08. Investigating highly crosslinked macroporous resins for solid-phase synthesis.. https://doi.org/10.1016/s0960-894x(98)00427-2

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