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PubMed · 9873549

A simple method for coupling aldehydes to solid support.

W A Metz·W D Jones·F L Ciske·N P Peet
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Abstract

A new method for attaching aldehydes to solid supports has been developed employing a 2,2-bis(hydroxymethyl)propionic acid (DMPA) functionalized resin. High loading levels are obtained for both aryl and alkyl aldehydes protected as their respective acetals. Treatment of the derivatized resin with 95% TFA then cleanly affords the recovered aldehyde in high yield.

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AldehydesCarboxylic AcidsChemistry, OrganicHydroxy AcidsKineticsPropionatesResins, SyntheticStructure-Activity RelationshipTrifluoroacetic AcidJournal Article

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W A Metz, W D Jones, F L Ciske, N P Peet. 1998-09-08. A simple method for coupling aldehydes to solid support.. https://doi.org/10.1016/s0960-894x(98)00434-x

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