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PubMed · 9876596

Alternative solvent-free preparation methods for felodipine surface solid dispersions.

J Kerc·S Srcic·B Kofler
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Abstract

Surface solid dispersions were prepared via physical mixture and were either heated in a vacuum dryer or in a microwave oven for different periods of time. The physical state of felodipine in solid dispersions was studied using differential scanning calorimetry and x-ray powder diffractometry. USP paddle method was used for felodipine dissolution studies. The use of vacuum or microwave energy led to a significant improvement of felodipine dissolution which was caused partly by the amorphous state of felodipine and a large surface area of amorphous silicon dioxide.

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Calcium Channel BlockersCalorimetry, Differential ScanningDrug CompoundingFelodipineHumansParticle SizeSolubilitySolventsSurface PropertiesX-Ray DiffractionComparative StudyJournal Article

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J Kerc, S Srcic, B Kofler. 1998. Alternative solvent-free preparation methods for felodipine surface solid dispersions.. https://doi.org/10.3109/03639049809085631

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