Chromatin disruption and modification.

A P Wolffe; J J Hayes

doi:10.1093/nar/27.3.711

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Chromatin disruption and modification.

A P Wolffe·J J Hayes

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Abstract

Chromatin disruption and modification are associated with transcriptional regulation by diverse coactivators and corepressors. Here we discuss the possible structural basis and functional consequences of the observed alterations in chromatin associated with transcriptional activation and repression. Recent advances in defining the roles of individual histones and their domains in the assembly and maintenance of regulatory architectures provide a framework for understanding how chromatin remodelling machines, histone acetyltransferases and deacetylases function.

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Amino Acid Sequence Animals Chromatin Histones Humans Models, Molecular Molecular Sequence Data Nucleosomes Structure-Activity Relationship Transcriptional Activation Journal Article Review

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A P Wolffe, J J Hayes. 1999-02-01. Chromatin disruption and modification.. https://doi.org/10.1093/nar%2F27.3.711

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